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J Rheumatol 2011 38:1502-6.BMI calculator Custom foods Trends Reports Your comparisons Profile Contribute Contact us Install app Endorsement of the definitions of disease activity states and improvement scores for the Ankylosing Spondylitis Disease Activity Score (ASDAS): results from the Outcome Measures in Rheumatology (OMERACT) 10 conference.
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Ankylosing Spondylitis Disease Activity Score (ASDAS): 2018 update of the nomenclature for disease activity states. Assessment of SpondyloArthritis international Society (ASAS). Machado PM, Landewé R, van der Heijde DV.Ankylosing Spondylitis Disease Activity Score (ASDAS): defining cut-off values for disease activity states and improvement scores. Machado P, Landewé R, Lie E, Kvien TK, Braun J, Baker D, van der Heijde D.ASDAS, a highly discriminatory ASAS-endorsed disease activity score in patients with ankylosing spondylitis.

van der Heijde D, Lie E, Kvien TK, Sieper J, van den Bosch F, Listing J, Braun J, Landewé R.

Development of an ASAS-endorsed disease activity score (ASDAS) in patients with ankylosing spondylitis. Lukas C, Landewé R, Sieper J, Dougados M, Davis J, Braun J, van der Linden S, van der Heijde D.Selected cut-offs for disease activity states. Selected cut-offs for improvement scores (figure 2) were: a change ≥1.1 units for “clinically important improvement” and a change ≥2.0 units for “major improvement” (3).įigure 1. The 3 cut-offs selected to separate these states (figure 1) were: 3.5 between “high disease activity” and “very high disease activity” (3,4). The methodology and the results were debated by ASAS members and four disease activity states were chosen by consensus: “inactive disease”, “moderate disease activity”, “high disease activity” and “very high disease activity”. During the 2010 ASAS workshop in Berlin, Germany, cut-offs for the ASDAS were proposed, and cross-validation studies were presented. The next step to consolidate the ASDAS as an instrument to measure disease activity in AS was the development of cut-offs for disease activity states and improvement scores. Apart from the value of CRP or ESR, the four additional self-reported items included in this index are back pain (0-10cm, visual analogue scale or 0-10, numerical rating scale ), duration of morning stiffness (VAS/NRS), peripheral pain/swelling (VAS/NRS) and patient global assessment of disease activity (VAS/NRS) (table 1) (1,2). The Assessment of SpondyloArthritis international Society (ASAS) membership has selected the ASDAS containing C-reactive protein (CRP, mg/l) as acute phase reactant as the preferred version, and the one with erythrocyte sedimentation rate (ESR, mm/hr) as the alternative version.
